Interaction of factors determining oxygen uptake at the onset of exercise

被引:190
作者
Tschakovsky, ME [1 ]
Hughson, RL [1 ]
机构
[1] Univ Waterloo, Dept Kinesiol, Waterloo, ON N2L 3G1, Canada
关键词
muscle energetics; mitochondrial respiration; oxygen delivery; exercise;
D O I
10.1152/jappl.1999.86.4.1101
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Considerable debate surrounds the issue of whether the rate of adaptation of skeletal muscle O-2 consumption ((Q) over dot O-2) at the onset of exercise is limited by 1) the inertia of intrinsic cellular metabolic signals and enzyme activation or 2) the availability of O-2 to the mitochondria, as determined by an extrinsic inertia of convective and diffusive O-2 transport mechanisms. This review critically examines evidence for both hypotheses and clarifies important limitations in the experimental and theoretical approaches to this issue. A review of biochemical evidence suggests that a given respiratory rate is a function of the net drive of phosphorylation potential and redox potential and cellular mitochondrial PO2 (PmitoO2) Changes in both phosphorylation and redox potential are determined by intrinsic metabolic inertia. PmitoO2 is determined by the extrinsic inertia of both convective and diffusive O-2 transport mechanisms during the adaptation to exercise and the rate of mitochondrial O-2 utilization. In a number of exercise conditions, PmitoO2 appears to be within a range capable of modulating muscle metabolism. Within this context, adjustments in the phosphate energy state of the cell would serve as a cytosolic "transducer," linking ATP consumption with mitochondrial ATP production and, therefore, O-2 consumption. The availability of reducing equivalents and O-2 would modulate the rate of adaptation of (Q) over dot O-2.
引用
收藏
页码:1101 / 1113
页数:13
相关论文
共 105 条
[31]   A SIMPLE-MODEL OF AEROBIC METABOLISM - APPLICATIONS TO WORK TRANSITIONS IN MUSCLE [J].
FUNK, CI ;
CLARK, A ;
CONNETT, RJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (06) :C995-C1005
[32]   MINIMUM INTRACELLULAR PO2 FOR MAXIMUM CYTOCHROME TURNOVER IN RED MUSCLE INSITU [J].
GAYESKI, TEJ ;
CONNETT, RJ ;
HONIG, CR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (05) :H906-H915
[33]   OXYGEN-TRANSPORT IN REST-WORK TRANSITION ILLUSTRATES NEW FUNCTIONS FOR MYOGLOBIN [J].
GAYESKI, TEJ ;
CONNETT, RJ ;
HONIG, CR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (06) :H914-H921
[34]   Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans [J].
Gerbino, A ;
Ward, SA ;
Whipp, BJ .
JOURNAL OF APPLIED PHYSIOLOGY, 1996, 80 (01) :99-107
[35]   Peripheral O2 diffusion does not affect Vo2 on-kinetics in isolated in situ canine muscle [J].
Grassi, B ;
Gladden, LB ;
Stary, CM ;
Wagner, PD ;
Hogan, MC .
JOURNAL OF APPLIED PHYSIOLOGY, 1998, 85 (04) :1404-1412
[36]   Gas exchange and cardiovascular kinetics with different exercise protocols in heart transplant recipients [J].
Grassi, B ;
Marconi, C ;
Meyer, M ;
Rieu, M ;
Cerretelli, P .
JOURNAL OF APPLIED PHYSIOLOGY, 1997, 82 (06) :1952-1962
[37]   Faster adjustment of O2 delivery does not affect Vo2 on-kinetics in isolated in situ canine muscle [J].
Grassi, B ;
Gladden, LB ;
Samaja, M ;
Stary, CM ;
Hogan, MC .
JOURNAL OF APPLIED PHYSIOLOGY, 1998, 85 (04) :1394-1403
[38]   Muscle O-2 uptake kinetics in humans: Implications for metabolic control [J].
Grassi, B ;
Poole, DC ;
Richardson, RS ;
Knight, DR ;
Erickson, BK ;
Wagner, PD .
JOURNAL OF APPLIED PHYSIOLOGY, 1996, 80 (03) :988-998
[39]  
HANSFORD RG, 1994, MED SCI SPORT EXER, V26, P44
[40]   Phosphocreatine hydrolysis during submaximal exercise:: the effect of FIO2 [J].
Haseler, LJ ;
Richardson, RS ;
Videen, JS ;
Hogan, MC .
JOURNAL OF APPLIED PHYSIOLOGY, 1998, 85 (04) :1457-1463