Role of stem cells in the regeneration and repair of peripheral nerves

被引：81

作者：

Ren, Zhiwu ^{[1
,2
]}

Wang, Yu ^{[1
]}

Peng, Jiang ^{[1
]}

Zhao, Qing ^{[1
]}

Lu, Shibi ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Inst Orthoped, Key Lab People Liberat Army, Beijing 100853, Peoples R China

[2] Nankai Univ, Coll Med, Tianjin 300071, Peoples R China

来源：

REVIEWS IN THE NEUROSCIENCES | 2012年 / 23卷 / 02期

关键词：

homing; peripheral nerve; regeneration; stem cell; tissue engineering; MARROW STROMAL CELLS; SCHWANN-CELLS; UMBILICAL-CORD; IN-VITRO; MULTILINEAGE DIFFERENTIATION; AXONAL REGENERATION; NEURITE OUTGROWTH; PROGENITOR CELLS; ADIPOSE-TISSUE; TRANSPLANTATION;

D O I：

10.1515/revneuro-2011-0069

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Peripheral nerve regeneration is a complex process, with Wallerian degeneration the most elementary reaction and Schwann cells playing an important role. In recent years, stem cells have been widely used to repair injured peripheral nerves. The sources of these stem cells are widespread and their effectiveness in the treatment of peripheral nerve injury may lie in their ability to differentiate into Schwann cells, secrete neurotrophic factors, and assist in myelin formation. Stem cells have been used as seed cells in tissue-engineered nerve grafts. The understanding of stem cell homing, novel repair material, and the ability to mobilize endogenous stem cells to assist peripheral nerve regeneration constitute a research direction of great interest.

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收藏

页码：135 / 143

页数：9

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