Role of stem cells in the regeneration and repair of peripheral nerves

被引：81

作者：

Ren, Zhiwu ^{[1
,2
]}

Wang, Yu ^{[1
]}

Peng, Jiang ^{[1
]}

Zhao, Qing ^{[1
]}

Lu, Shibi ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Inst Orthoped, Key Lab People Liberat Army, Beijing 100853, Peoples R China

[2] Nankai Univ, Coll Med, Tianjin 300071, Peoples R China

来源：

REVIEWS IN THE NEUROSCIENCES | 2012年 / 23卷 / 02期

关键词：

homing; peripheral nerve; regeneration; stem cell; tissue engineering; MARROW STROMAL CELLS; SCHWANN-CELLS; UMBILICAL-CORD; IN-VITRO; MULTILINEAGE DIFFERENTIATION; AXONAL REGENERATION; NEURITE OUTGROWTH; PROGENITOR CELLS; ADIPOSE-TISSUE; TRANSPLANTATION;

D O I：

10.1515/revneuro-2011-0069

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Peripheral nerve regeneration is a complex process, with Wallerian degeneration the most elementary reaction and Schwann cells playing an important role. In recent years, stem cells have been widely used to repair injured peripheral nerves. The sources of these stem cells are widespread and their effectiveness in the treatment of peripheral nerve injury may lie in their ability to differentiate into Schwann cells, secrete neurotrophic factors, and assist in myelin formation. Stem cells have been used as seed cells in tissue-engineered nerve grafts. The understanding of stem cell homing, novel repair material, and the ability to mobilize endogenous stem cells to assist peripheral nerve regeneration constitute a research direction of great interest.

引用

收藏

页码：135 / 143

页数：9

相关论文

共 105 条

[71]

STUDIES ON VASCULAR PERMEABILITY IN PERIPHERAL NERVES .1. DISTRIBUTION OF CIRCULATING FLUOREESCENT SERUM ALBUMIN IN NORMAL CRUSHED AND SECTIONED RAT SCIATIC NERVE [J].

OLSSON, Y .

ACTA NEUROPATHOLOGICA, 1966, 7 (01) :1-&

[72]

Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway [J].

Otsuru, Satoru ;

Tamai, Katsuto ;

Yamazaki, Takehiko ;

Yoshikawa, Hideki ;

Kaneda, Yasufumi .

STEM CELLS, 2008, 26 (01) :223-234

[73]

CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination [J].

Patel, Jigisha R. ;

McCandless, Erin E. ;

Dorsey, Denise ;

Klein, Robyn S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (24) :11062-11067

[74]

ROLE OF MACROPHAGES IN PERIPHERAL-NERVE DEGENERATION AND REPAIR [J].

PERRY, VH ;

BROWN, MC .

BIOESSAYS, 1992, 14 (06) :401-406

[75]

Multilineage potential of adult human mesenchymal stem cells [J].

Pittenger, MF ;

Mackay, AM ;

Beck, SC ;

Jaiswal, RK ;

Douglas, R ;

Mosca, JD ;

Moorman, MA ;

Simonetti, DW ;

Craig, S ;

Marshak, DR .

SCIENCE, 1999, 284 (5411) :143-147

[76]

Sonographic measurement of the umbilical cord and fetal anthropometric parameters [J].

Raio, L ;

Ghezzi, F ;

Di Naro, E ;

Gomez, R ;

Franchi, M ;

Mazor, M ;

Brühwiler, H .

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1999, 83 (02) :131-135

[77]

TROPHIC ACTIVITY DERIVED FROM BONE MARROW MONONUCLEAR CELLS INCREASES PERIPHERAL NERVE REGENERATION BY ACTING ON BOTH NEURONAL AND GLIAL CELL POPULATIONS [J].

Ribeiro-Resende, V. T. ;

Pimentel-Coelho, P. M. ;

Mesentier-Louro, L. A. ;

Mendez, R. M. B. ;

Mello-Silva, J. P. C. ;

Cabral-Da-Silva, M. C. ;

De Mello, F. G. ;

Reis, R. A. De Melo ;

Mendez-Otero, R. .

NEUROSCIENCE, 2009, 159 (02) :540-549

[78]

QUANTITATION OF SCHWANN-CELLS AND ENDONEURIAL FIBROBLAST-LIKE CELLS AFTER EXPERIMENTAL NERVE TRAUMA [J].

SALONEN, V ;

AHO, H ;

ROYTTA, M ;

PELTONEN, J .

ACTA NEUROPATHOLOGICA, 1988, 75 (04) :331-336

[79]

Adult bone marrow stromal cells differentiate into neural cells in vitro [J].

Sanchez-Ramos, J ;

Song, S ;

Cardozo-Pelaez, F ;

Hazzi, C ;

Stedeford, T ;

Willing, A ;

Freeman, TB ;

Saporta, S ;

Janssen, W ;

Patel, N ;

Cooper, DR ;

Sanberg, PR .

EXPERIMENTAL NEUROLOGY, 2000, 164 (02) :247-256

[80]

Concise review:: Adipose tissue-derived stromal cells -: Basic and clinical implications for novel cell-based therapies [J].

Schaeffler, Andreas ;

Buechler, Christa .

STEM CELLS, 2007, 25 (04) :818-827

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