Crosstalk between TGF-β signaling and the microRNA machinery

被引：243

作者：

Butz, Henriett ^{[2
]}

Racz, Karoly ^{[2
]}

Hunyady, Laszlo ^{[3
]}

Patocs, Attila ^{[1
,4
]}

机构：

[1] Hungarian Acad Sci, Mol Med Res Grp, Budapest, Hungary

[2] Semmelweis Univ, Fac Med, Dept Med 2, H-1085 Budapest, Hungary

[3] Semmelweis Univ, Dept Physiol, H-1085 Budapest, Hungary

[4] Semmelweis Univ, Dept Lab Med, H-1085 Budapest, Hungary

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2012年 / 33卷 / 07期

关键词：

GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; INDUCED COLLAGEN EXPRESSION; HUMAN ADIPOSE-TISSUE; MESSENGER-RNA; DOWN-REGULATION; MIR-200; FAMILY; CANCER-CELLS; STEM-CELLS; RENAL FIBROSIS;

D O I：

10.1016/j.tips.2012.04.003

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The activin/transforming growth factor-beta (TGF-beta) pathway plays an important role in tumorigenesis either by its tumor suppressor or tumor promoting effect. Loss of members of the TGF-beta signaling by somatic mutations or epigenetic events, such as DNA methylation or regulation by microRNA (miRNA), may affect the signaling process. Most members of the TGF-beta pathway are known to be targeted by one or more miRNAs. In addition, the biogenesis of miRNAs is also regulated by TGF-beta both directly and through SMADs. Based on these interactions, it appears that autoregulatory feedback loops between TGF-beta and miRNAs influence the fate of tumor cells. Our aim is to review the crosstalk between TGF-beta signaling and the miRNA machinery to highlight potential novel therapeutic targets.

引用

页码：382 / 393

页数：12

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