Application of in situ product-removal techniques to biocatalytic processes

被引：183

作者：

Lye, GJ ^{[1
]}

Woodley, JM ^{[1
]}

机构：

[1] UCL, Ctr Biochem Engn, Adv Ctr Biochem Engn, London WC1E 7JE, England

来源：

TRENDS IN BIOTECHNOLOGY | 1999年 / 17卷 / 10期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0167-7799(99)01351-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biocatalytic processes for the manufacture of small, highly functionalized molecules frequently have limited productivity. A common reason for this is the presence of the reaction products that can cause inhibitory or toxic effects (making poor use of the enzyme) or promote unfavourable equilibria (giving low conversions). In each case, the product needs to be removed as soon as it is formed in order to overcome these constraints and hence increase the productivity of the biocatalytic process. Here, we review the need for in situ product removal and the process research required for its implementation.

引用

页码：395 / 402

页数：8

共 57 条

[1] Directed evolution: Creating biocatalysts for the future [J].

Arnold, FH .

CHEMICAL ENGINEERING SCIENCE, 1996, 51 (23) :5091-5102

[2] COUNTERCURRENT CHROMATOGRAPHY AS AN ENZYMATIC REACTOR FOR ORGANIC-SYNTHESIS [J].

BOUSQUET, OR ;

BRAUN, J ;

LEGOFFIC, F .

TETRAHEDRON LETTERS, 1995, 36 (45) :8195-8196

[3] Carbon-carbon bond synthesis - Preparation and use of immobilized transketolase [J].

Brocklebank, SP ;

Mitra, RK ;

Woodley, JM ;

Lilly, MD .

ENZYME ENGINEERING XIII, 1996, 799 :729-736

[4] SOLVENT SELECTION-STRATEGIES FOR EXTRACTIVE BIOCATALYSIS [J].

BRUCE, LJ ;

DAUGULIS, AJ .

BIOTECHNOLOGY PROGRESS, 1991, 7 (02) :116-124

[5] Microbial Conversion of Indene to Indandiol: A Key Intermediate in the Synthesis of CRIXIVAN [J].

Buckland, Barry C. ;

Drew, Stephen W. ;

Connors, Neal C. ;

Chartrain, Michel M. ;

Lee, Chanyong ;

Salmon, Peter M. ;

Gbewonyo, Kodzo ;

Zhou, Weichang ;

Gailliot, Pat ;

Singhvi, Rahul ;

Olewinski, Roger C., Jr. ;

Sun, Wen-Jun ;

Reddy, Jayanthi ;

Zhang, Jinyou ;

Jackey, Barbara A. ;

Taylor, Colleen ;

Goklen, Kent E. ;

Junker, Beth ;

Greasham, Randolph L. .

METABOLIC ENGINEERING, 1999, 1 (01) :63-74

[6] GENERATION OF A PH GRADIENT IN AN IMMOBILIZED ENZYME-SYSTEM [J].

BYERS, JP ;

SHAH, MB ;

FOURNIER, RL ;

VARANASI, S .

BIOTECHNOLOGY AND BIOENGINEERING, 1993, 42 (04) :410-420

[7] Biotransformation of dicarboxylic acid by immobilized Cryptococcus cells [J].

Chan, EC ;

Kuo, J .

ENZYME AND MICROBIAL TECHNOLOGY, 1997, 20 (08) :585-589

[8] In situ product removal from E-coli transketolase-catalyzed biotransformations [J].

Chauhan, RP ;

Woodley, JM ;

Powell, LW .

ENZYME ENGINEERING XIII, 1996, 799 :545-554

[9]

Chauhan RP, 1997, CHEMTECH, V27, P26

[10]

Chauhan RP, 1997, BIOTECHNOL BIOENG, V56, P345, DOI 10.1002/(SICI)1097-0290(19971105)56:3<345::AID-BIT13>3.0.CO

← 1 2 3 4 5 6 →