Screening of a supramolecular catalyst library in the search for selective catalysts for the asymmetric hydrogenation of a difficult enamide substrate

被引：153

作者：

Jiang, XB

Lefort, L

Goudriaan, PE

de Vries, AHM

van Leeuwen, PWNM

de Vries, JG

Reek, JNH

机构：

[1] Univ Amsterdam, Homogeneous Catalysis Van Hoff Inst Mol Sci, NL-1018 WV Amsterdam, Netherlands

[2] DSM Res & Patents, DSM Pharma Chem Adv Synth Catalysis & Dev, NL-6160 MD Geleen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 08期

关键词：

asymmetric catalysis; combinatorial chemistry; high-throughput screening; self-assembly; supramolecular chemistry;

D O I：

10.1002/anie.200503663

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Bindings for libraries: Large numbers of bidentate ligands have been formed from two monodentate ligands (one based on zinc(II) porphyrin and the other on a substituted phosphane) by using high-throughput methods combined with self-assembly principles. The library provided a Rh catalyst that hydrogenates the enamide 1 with the highest enantioselectivity known to date. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1223 / 1227

页数：5

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