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PipPhos and MorfPhos: Privileged monodentate phosphoramidite ligands for rhodium-catalyzed asymmetric hydrogenation

被引：165
作者：
Bernsmann, H
van den Berg, M
Hoen, R
Minnaard, AJ
Mehler, G
Reetz, MT
De Vries, JG
Feringa, BL
机构：
[1] Univ Groningen, Stratingh Inst, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands
[2] DSM Res & Patents, Life Sci Adv Synth Catalysis & Dev, NL-6160 MD Geleen, Netherlands
[3] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 03期
关键词：
D O I：
10.1021/jo048374o
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A library of 20 monodentate phosphoramidite ligands has been prepared and applied in rhodium-catalyzed asymmetric hydrogenation. This resulted in the identification of two ligands, PipPhos and MorfPhos, that afford excellent and in several cases unprecedented enantioselectivities in the hydrogenation of N-acyldehydroamino acid esters, dimethyl itaconate, acyclic N-acylenamides, and cyclic N-acylenamides. In addition, a method for the parallel enantioselectivity determination of eight acylated amines is presented.
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页码：943 / 951
页数：9
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