Suppression of experimental autoimmune encephalomyelitis (EAE) by intraperitoneal administration of soluble myelin antigens in Wistar rats

被引：23

作者：

Rivero, VE ^{[1
]}

Maccioni, M ^{[1
]}

Bucher, AE ^{[1
]}

Roth, GA ^{[1
]}

Riera, CM ^{[1
]}

机构：

[1] UNIV NACL CORDOBA,FAC CIENCIAS QUIM,DEPT QUIM BIOL,CIQUIBIC,CONICET,RA-5016 CORDOBA,ARGENTINA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1997年 / 72卷 / 01期

关键词：

experimental autoimmune encephalomyelitis; autoimmunity; suppression; myelin basic protein; immunoglobulin isotypes;

D O I：

10.1016/S0165-5728(96)00117-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intraperitoneal (i.p.) treatment of Wistar rats with bovine myelin (BM) or myelin basic protein (MBP) previously to immunization with BM-CFA showed a diminished incidence and severity of experimental autoimmune encephalomyelitis (EAE) (2/13 and 0/7, respectively) when compared with rats immunized with BM-CFA (11/17) or i.p. treated with ovalbumin (2/4). Concomitantly, animals treated with BM or MBP exhibited a marked reduction of proliferative response to MBP which was highly positive when spleen mononuclear cells from nontreated and ovalbumin treated animals were assayed. Rats that were treated with MBP before immunization produce IgA, IgM, total IgG and subclasses of IgG, IgG2a, IgG2b, IgG2c specific for MBP in similar levels than those observed in nontreated immunized animals. However, a higher incidence and level of IgG1 was observed in MBP treated rats, meanwhile rats i.p. treated with total BM showed a highly reduced humoral response. The herein presented results show that i.p. treatment with low amounts of soluble forms of myelin antigens markedly reduced the clinical symptoms of the disease, the histological alterations, the cellular proliferative response to MBP, and produced changes in the autoimmune humoral response.

引用

页码：3 / 10

页数：8

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