Concerning the absorption and photochemical properties of an ω-4-eimethylaminobenzal hypericin derivative

被引：16

作者：

Obermüller, RA ^{[1
]}

Falk, H ^{[1
]}

机构：

[1] Johannes Kepler Univ Linz, Inst Chem, A-4040 Linz, Austria

来源：

MONATSHEFTE FUR CHEMIE | 2001年 / 132卷 / 12期

关键词：

photodynamic therapy; bilirubin photooxidation; bathochromic shift; fluorescence; intramolecular cycloaddition;

D O I：

10.1007/s007060170009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hypericin derivative containing omega,omega'-4-dimethylaminobenzal residues was shown to undergo an intramolecular [2 + 2] cycloaddition upon irradiation leading to a cyclobutane derivative whose main absorption band is hardly shifted as compared to hypericin. The corresponding omega-substituted derivative displayed a 34 nm bathochromic shift and a strongly reduced fluorescence quantum yield rendering it a nice candidate for a photodynamic therapy agent. Unfortunately, however, it produced virtually no photosensitized active oxygen species, making it thus unsuited for this purpose.

引用

页码：1519 / 1526

页数：8

共 23 条

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0211:THDPPT&gt

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