Nonsense-mediated mRNA decay in health and disease

被引：833

作者：

Frischmeyer, PA

Dietz, HC ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21205 USA

来源：

HUMAN MOLECULAR GENETICS | 1999年 / 8卷 / 10期

关键词：

D O I：

10.1093/hmg/8.10.1893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All eukaryotes possess the ability to detect and degrade transcripts harboring premature signals for the termination of translation. Despite the ubiquitous nature of nonsense-mediated mRNA decay (NMD) and its demonstrated role in the modulation of phenotypes resulting from selected nonsense alleles, very little is known regarding its basic mechanism or the selective pressure for complete evolutionary conservation of this function. This review will present the current models of NMD that have been generated during the study of model organisms and mammalian cells. The physiological burden of nonsense transcripts and the emerging view that NMD plays a broad and critical role in the regulation of gene expression will also be discussed. Such issues are relevant to the proposal that pharmacological manipulation of NMD will find therapeutic application.

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页码：1893 / 1900

页数：8

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