Asymmetric total synthesis of (-)-nakadomarin A

被引：73

作者：

Ono, K ^{[1
]}

Nakagawa, M ^{[1
]}

Nishida, A ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 15期

关键词：

alkaloids; cyclization; metathesis; natural products; total synthesis;

D O I：

10.1002/anie.200453673

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A key intermediate in the first asymmetric synthesis of the marine alkaloid (-)-nakadomarin A (1), isolated from the marine sponge Amphimedon sp., was the optically active hydroisoquinoline 2. Two separate ring-closing-metathesis reactions were crucial to the construction of the 15- and 8-membered rings.

引用

页码：2020 / 2023

页数：4

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