Bioactive products from marine micro- and macro-organsms

被引：51

作者：

Kobayashi, J ^{[1
]}

Tsuda, M ^{[1
]}

Ishibashi, M ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 06期

关键词：

D O I：

10.1351/pac199971061123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel 37-membered macrolides, theonezolides A similar to C, and two novel manzamine-related alkaloids, nakadomarin A and ma'eganedin A, were isolated from Okinawan marine sponges, while three new polyhydroxyl compounds, luteophanols A similar to C, were obtained from a marine dinoflagellate. The structures were elucidated on the basis of the spectroscopic data. The absolute stereochemistry of the C-4 similar to C-17 fragment of theonezolides A similar to C was established by synthetic studies, and a plausible biogenetic path of nakadomarin A was proposed.

引用

页码：1123 / 1126

页数：4

共 11 条

[1] Luteophanol A, a new polyhydroxyl compound from symbiotic marine dinoflagellate Amphidinium sp. [J].

Doi, Y ;

Ishibashi, M ;

Nakamichi, H ;

Kosaka, T ;

Ishikawa, T ;

Kobayashi, J .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (12) :3820-3823

[2]

Ishibashi M, 1997, HETEROCYCLES, V44, P543

[3] Studies on the stereochemistry of theonezolides A-C1:: Elucidation of the relative configurations of 1,3-diol moieties of the C-4∼C-17 fragment [J].

Kobayashi, J ;

Yonezawa, M ;

Takeuchi, S ;

Ishibashi, M .

HETEROCYCLES, 1998, 49 :39-42

[4] THEONEZOLIDE-A - A NOVEL POLYKETIDE NATURAL PRODUCT FROM THE OKINAWAN MARINE SPONGE THEONELLA SP [J].

KOBAYASHI, J ;

KONDO, K ;

ISHIBASHI, M ;

WALCHLI, MR ;

NAKAMURA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (15) :6661-6665

[5] Nakadomarin A, a novel hexacyclic manzamine-related alkaloid from Amphimedon sponge [J].

Kobayashi, J ;

Watanabe, D ;

Kawasaki, N ;

Tsuda, M .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (26) :9236-9239

[6] ISOLATION AND STRUCTURES OF THEONEZOLIDE-B AND THEONEZOLIDE-C FROM THE OKINAWAN MARINE SPONGE THEONELLA SP [J].

KONDO, K ;

ISHIBASHI, M ;

KOBAYASHI, J .

TETRAHEDRON, 1994, 50 (28) :8355-8362

[7] Luteophanols B and C, new polyhydroxyl compounds from marine dinoflagellate Amphidinium sp [J].

Kubota, T ;

Tsuda, M ;

Doi, Y ;

Takahashi, A ;

Nakamichi, H ;

Ishibashi, M ;

Fukushi, E ;

Kawabata, J ;

Kobayashi, J .

TETRAHEDRON, 1998, 54 (48) :14455-14464

[8] The mode of rabbit platelet shape change and aggregation induced by theonezolide-A, a novel polyketide macrolide, isolated from the Okinawan marine sponge Theonella sp [J].

Rho, MC ;

Park, YH ;

Sasaki, S ;

Ishibashi, M ;

Kondo, K ;

Kobayashi, J ;

Ohizumi, Y .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1996, 74 (02) :193-199

[9] Studies on stereochemistry of theonezolides A∼C1:: Determination of absolute stereochemistry of the C-4∼C-17 fragment [J].

Sato, M ;

Takeuchi, S ;

Ishibashi, M ;

Kobayashi, J .

TETRAHEDRON, 1998, 54 (19) :4819-4826

[10] Ma'eganedin A, a new manzamine alkaloid from Amphimedon sponge [J].

Tsuda, M ;

Watanabe, D ;

Kobayashi, J .

TETRAHEDRON LETTERS, 1998, 39 (10) :1207-1210

← 1 2 →