Transcriptional corepression by SHP:: molecular mechanisms and physiological consequences

被引：121

作者：

Båvner, A ^{[1
]}

Sanyal, S ^{[1
]}

Gustafsson, JÅ ^{[1
]}

Treuter, E ^{[1
]}

机构：

[1] Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2005年 / 16卷 / 10期

关键词：

D O I：

10.1016/j.tem.2005.10.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Small heterodimer partner (SHP; NR0B2), an exceptional member of the mammalian nuclear receptor family, directly modulates the activities of conventional nuclear receptors by acting as an inducible and tissue-specific corepressor. Recent progress in dissecting underlying molecular mechanisms, identifying target factors and target genes, and uncovering physiological functions points to the regulatory involvement of SHP in diverse metabolic and intracellular pathways that awaits future clarification. In this review, we carry out a comprehensive survey of all published data and discuss our current understanding of molecular mechanisms and physiological consequences governing SHP action.

引用

页码：478 / 488

页数：11

共 77 条

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