Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro

被引：156

作者：

Alekshun, MN

Levy, SB

机构：

[1] Tufts Univ, Sch Med, Ctr Adaptat Genet & Drug Resistance, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

[3] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 15期

关键词：

D O I：

10.1128/JB.181.15.4669-4672.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

MarR negatively regulates expression of the multiple antibiotic resistance operon (marRAB) in Escherichia coli. In this study, it was demonstrated that sodium salicylate, plumbagin, 2,4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affect its repressor activity.

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页码：4669 / 4672

页数：4

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