Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zonoosis

被引：73

作者：

Weber, Friedemann ^{[2
]}

Mirazimi, Ali ^{[1
,3
]}

机构：

[1] Swedish Inst Infect Dis Control, Ctr Microbiol Preparedness, SE-17182 Solna, Sweden

[2] Univ Freiburg, Dept Virol, D-79008 Freiburg, Germany

[3] Swedish Inst Infect Dis Control, Ctr Microbiol Preparedness, Stockholm, Sweden

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2008年 / 19卷 / 5-6期

关键词：

Crimean Congo Hemorrhagic fever virus; Pathogenesis; Cytokines; Interferon; CCHFv;

D O I：

10.1016/j.cytogfr.2008.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crimean Congo hemorrhagic fever virus (CCHFV) causes an acute disease with the potential of a fatal outcome. The virus is prevalent in about 30 countries, Clinical symptoms of infection commonly include fever, myalgia, and hemorrhages. Levels of liver enzymes are raised, and bleeding markers are often increased. A role of inflammatory cytokines in the pathogenesis has been suggested, and CCHFV employs a range of passive and active mechanisms to avoid induction of the antiviral type I interferons. Here, we review the most recent findings on the molecular pathogenesis and the interaction of CCHFV with the type I interferon and cytokine responses and discuss implications for pathogenesis. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：395 / 404

页数：10

共 122 条

[101] Bi-annual surge of Crimean-Congo haemorrhagic fever (CCHF): a five-year experience [J].