Cellular functions of the plasma membrane estrogen receptor

被引：148

作者：

Levin, ER ^{[1
]}

机构：

[1] Vet Affairs Med Ctr, Div Endocrinol, Long Beach, CA 90822 USA

[2] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA

[3] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 09期

关键词：

D O I：

10.1016/S1043-2760(99)00192-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The existence of an estrogen receptor (ER) on the plasma membrane has been supported by data emerging from numerous laboratories over the past 20 years. However, this receptor has not yet been isolated. Original reports of a cell membrane protein that could bind and rapidly respond to 17 beta-estradiol (E-2) were supported by evidence that a putative membrane receptor could effect a variety of signal transduction events. Recent studies have shown that the nongenomic actions of E-2 can be mediated through the plasma membrane ER.

引用

页码：374 / 377

页数：4

共 48 条

[1] ESTROGEN ACTION VIA THE CAMP SIGNALING PATHWAY - STIMULATION OF ADENYLATE-CYCLASE AND CAMP-REGULATED GENE-TRANSCRIPTION [J].

ARONICA, SM ;

KRAUS, WL ;

KATZENELLENBOGEN, BS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (18) :8517-8521

[2] 17-BETA ESTRADIOL PROTECTS NEURONS FROM OXIDATIVE STRESS-INDUCED CELL-DEATH IN-VITRO [J].

BEHL, C ;

WIDMANN, M ;

TRAPP, T ;

HOLSBOER, F .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 216 (02) :473-482

[3]

BLACKMORE PF, 1991, J BIOL CHEM, V266, P18655

[4] Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation [J].

Bunone, G ;

Briand, PA ;

Miksicek, RJ ;

Picard, D .

EMBO JOURNAL, 1996, 15 (09) :2174-2183

[5] Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen [J].

Chen, Z ;

Yuhanna, IS ;

Galcheva-Gargova, Z ;

Karas, RH ;

Mendelsohn, RE ;

Shaul, PW .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (03) :401-406

[6] Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors [J].

Daub, H ;

Weiss, FU ;

Wallasch, C ;

Ullrich, A .

NATURE, 1996, 379 (6565) :557-560

[7]

Farhat MY, 1996, J PHARMACOL EXP THER, V276, P652

[8] Membrane binding sites and non-genomic effects of estrogen in cultured human pre-osteoclastic cells [J].

Fiorelli, G ;

Gori, F ;

Frediani, U ;

Franceschelli, F ;

Tanini, A ;

TostiGuerra, C ;

Benvenuti, S ;

Gennari, L ;

Becherini, L ;

Brandi, ML .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1996, 59 (02) :233-240

[9] GLUCOCORTICOID RECEPTOR LIKE ANTIGEN IN LYMPHOMA CELL-MEMBRANES - CORRELATION TO CELL-LYSIS [J].

GAMETCHU, B .

SCIENCE, 1987, 236 (4800) :456-461

[10] A novel, synergistic interaction between 17 β-estradiol and glutathione in the protection of neurons against β-amyloid 25-35-induced toxicity in vitro [J].

Gridley, KE ;

Green, PS ;

Simpkins, JW .

MOLECULAR PHARMACOLOGY, 1998, 54 (05) :874-880

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