Cellular functions of the plasma membrane estrogen receptor

被引：148

作者：

Levin, ER ^{[1
]}

机构：

[1] Vet Affairs Med Ctr, Div Endocrinol, Long Beach, CA 90822 USA

[2] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA

[3] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 09期

关键词：

D O I：

10.1016/S1043-2760(99)00192-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The existence of an estrogen receptor (ER) on the plasma membrane has been supported by data emerging from numerous laboratories over the past 20 years. However, this receptor has not yet been isolated. Original reports of a cell membrane protein that could bind and rapidly respond to 17 beta-estradiol (E-2) were supported by evidence that a putative membrane receptor could effect a variety of signal transduction events. Recent studies have shown that the nongenomic actions of E-2 can be mediated through the plasma membrane ER.

引用

页码：374 / 377

页数：4

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