BADASP: predicting functional specificity in protein families using ancestral sequences

被引：18

作者：

Edwards, RJ ^{[1
]}

Shields, DC ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Dublin 2, Ireland

来源：

BIOINFORMATICS | 2005年 / 21卷 / 22期

基金：

爱尔兰科学基金会;

关键词：

D O I：

10.1093/bioinformatics/bti678

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Burst After Duplication with Ancestral Sequence Predictions (BADASP) is a software package for identifying sites that may confer subfamily-specific biological functions in protein families following functional divergence of duplicated proteins. A given protein phylogeny is grouped into subfamilies based on orthology/paralogy relationships and/or user definitions. Ancestral sequences are then predicted from the sequence alignment and the functional specificity is calculated using variants of the Burst After Duplication method, which tests for radical amino acid substitutions following gene duplications that are subsequently conserved. Statistics are output along with subfamily groupings and ancestral sequences for an easy analysis with other packages.

引用

页码：4190 / 4191

页数：2

共 14 条

[1] FunShift: a database of function shift analysis on protein subfamilies [J].