Synthesis of di- and trisubstituted guanidines on multivalent soluble supports

被引：17

作者：

Chang, J ^{[1
]}

Oyelaran, O ^{[1
]}

Esser, CK ^{[1
]}

Kath, GS ^{[1
]}

King, GW ^{[1
]}

Uhrig, BG ^{[1
]}

Konteatis, Z ^{[1
]}

Kim, RM ^{[1
]}

Chapman, KT ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(99)00812-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of 48 di- and trisubstituted guanidines was synthesized on a soluble, tetravalent support. Support-bound intermediates and cleaved products were isolated in parallel by size exclusion chromatography using a semiautomated system. Products were generally obtained in good yield and purity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4477 / 4480

页数：4

共 22 条

[1]

Balkenhohl F, 1996, ANGEW CHEM INT EDIT, V35, P2289

[2] LIQUID-PHASE SYNTHESIS OF PEPTIDES [J].