Solid-phase synthesis of N,N′ substituted guanidines

被引：61

作者：

Dodd, DS ^{[1
]}

Wallace, OB ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Combinatorial Drug Discovery, Wallingford, CT 06492 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(98)01197-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

All efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N'-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated front the resin upon exposure to ammonia or primary amines. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5701 / 5704

页数：4

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