Solid-phase synthesis of disubstituted guanidines

被引:52
作者
Kearney, PC [1 ]
Fernandez, M [1 ]
Flygare, JA [1 ]
机构
[1] Tularik Inc, S San Francisco, CA 94080 USA
关键词
D O I
10.1016/S0040-4039(98)00373-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A method for the solid-phase synthesis of disubstituted guanidines is reported. In this procedure, polymer-bound aryl or alkyl amines are converted to methyl isothioureas in three steps and treated with primary and secondary amines to form the disubstituted guanidine products. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2663 / 2666
页数:4
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