Solid phase synthesis of guanidines

被引：64

作者：

Robinson, S ^{[1
]}

Roskamp, EJ ^{[1
]}

机构：

[1] PFIZER INC,CENT RES,GROTON,CT 06340

来源：

TETRAHEDRON | 1997年 / 53卷 / 19期

关键词：

D O I：

10.1016/S0040-4020(97)00225-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A comparison of guanylating agents 1 and 2 was performed on a series of primary, secondary and aromatic amines in solution and on solid phase resins. Thiourea 1 performed well in solution and on solid supported primary and secondary amines. Pyrazole 2 performed well in each case, except one aniline which failed to react. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：6697 / 6705

页数：9

共 19 条

[1] 1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE - AN ATTRACTIVE REAGENT FOR GUANYLATION OF AMINES AND ITS APPLICATION TO PEPTIDE-SYNTHESIS [J].