Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis

被引：35

作者：

Ailixiding, Maierhaba ^{[1
]}

Aibibula, Zulipiya ^{[2
]}

Iwata, Munetaka ^{[3
]}

Piao, Jinying ^{[2
]}

Hara, Yasushi ^{[3
]}

Koga, Daisuke ^{[2
]}

Okawa, Atsushi ^{[2
]}

Morita, Sadao ^{[1
]}

Asou, Yoshinori ^{[2
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Rehabil Med, Bunkyo Ku, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Dept Orthoped Surg, Bunkyo Ku, Tokyo 1138519, Japan

[3] Nippon Vet & Life Sci Univ, Div Vet Surg, Musashino, Tokyo 1808602, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 466卷 / 03期

关键词：

Sirt6; Osteoarthritis; Metabolic syndrome; Infrapatellar fat pad; Ageing; INFRAPATELLAR FAT PAD; DIET; INFLAMMATION; ACTIVATION; OVERWEIGHT; OBESITY; KNEE; LIFE;

D O I：

10.1016/j.bbrc.2015.09.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoarthritis (OA) is a chronic degenerative joint disorder commonly associated with metabolic syndrome. As ageing and obesity has a great impact on the initiation/severity of OA, herein we sought to investigate the involvement of Sirt6 in the crosstalk between ageing and metabolic syndrome/OA. Sirt6 haploinsufficiency in mice promoted the expression of inflammatory cytokines in the IPFP. Enhanced inflammation of the IPFP in the aged Sirt6 +/- HFD group was paralleled with accelerated OA change, including osteophyte growth and chondrocyte hypertrophy. Conversely, mesenchyme-specific Sirt6-deficient mice revealed both attenuated chondrocyte hypertrophy and proteoglycan synthesis, although chondrocyte senescence was enhanced as shown in the aged WT mice. Thus Sirt6 has key roles in the relationship among ageing, metabolic syndrome, and OA. (C) 2015 The Authors. Published by Elsevier Inc.

引用

页码：319 / 326

页数：8

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