A1C but Not Serum Glycated Albumin Is Elevated in Late Pregnancy Owing to Iron Deficiency

被引:106
作者
Hashimoto, Kunihiko [2 ]
Noguchi, Sanai [2 ]
Morimoto, Yasuhiko [2 ]
Hamada, Shinichi [3 ]
Wasada, Kenshi [3 ]
Imai, Shiro [3 ]
Murata, Yuji [3 ]
Kasayama, Soji [4 ]
Koga, Masafumi [1 ]
机构
[1] Kinki Cent Hosp, Dept Med, Kobe, Hyogo, Japan
[2] Aizenbashi Hosp, Dept Med, Osaka, Japan
[3] Aizenbashi Hosp, Dept Gynecol & Obstet, Osaka, Japan
[4] Nissay Hosp, Dept Med, Osaka, Japan
关键词
D O I
10.2337/dc08-0352
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - A1C levels have been shown to be elevated in relation to glycemia in late pregnancy, although the precise mechanisms remain undetermined. We hypothesized that iron deficiency is involved in the A1C increase in late pregnancy. RESEARCH DESIGN AND METHODS - In study 1, A1C, serum glycated albumin, erythrocyte indexes, and iron metabolism indexes were determined in 47 nondiabetic pregnant women not receiving iron supplementation who were divided into four groups according to gestational period (group I, 21-24 weeks; group II, 25-28 weeks; group III, 29-32 weeks; and group IV, 33-36 weeks). In study 2, these determinants were obtained at two gestational periods (20-23 weeks and 32-33 weeks) in 1.7 nondiabetic pregnant women. RESULTS - In study 1, A1C levels were higher in groups III and IV than those in groups I and II, whereas serum glycated albumin levels were not different among these [Our groups. Hemoglobin, mean corpuscular hemoglobin (MCH), serum transferrin saturation, and serum ferritin were lower in groups III and IV. A1C levels were negatively correlated with MCH, serum transferrin Saturation, and serum ferritin. In Study 2, A1C levels Were Significantly increased at gestational weeks 32-33 from those at weeks 20-23, whereas serum glycated albumin levels did not differ between the two gestational periods. MCH, serum transferrin saturation, and serum ferritin were decreased at gestational weeks 32-33. A1C levels showed a negative correlation with MCH, Serum transferrin Saturation, and serum ferritin. CONCLUSIONS - A1C levels were elevated in late pregnancy owing to iron deficiency Serum glycated albumin may offer a better index for monitoring glycemic control in pregnancy
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页码:1945 / 1948
页数:4
相关论文
共 22 条
[1]  
*AM DIAB ASS, 2004, DIABETES CARE S1, V27, pS15
[2]  
BROOKS AP, 1980, LANCET, V2, P141
[3]   GLYCOSYLATION OF HEMOGLOBIN - RELEVANCE TO DIABETES-MELLITUS [J].
BUNN, HF ;
GABBAY, KH ;
GALLOP, PM .
SCIENCE, 1978, 200 (4337) :21-27
[4]   Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients [J].
Coban, E ;
Ozdogan, M ;
Timuragaoglu, A .
ACTA HAEMATOLOGICA, 2004, 112 (03) :126-128
[5]   24-HOUR EXCURSION AND DIURNAL RHYTHM OF GLUCOSE, INSULIN, AND C-PEPTIDE IN NORMAL-PREGNANCY [J].
COUSINS, L ;
RIGG, L ;
HOLLINGSWORTH, D ;
BRINK, G ;
AURAND, J ;
YEN, SSC .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1980, 136 (04) :483-488
[6]   Macrosomia despite good glycaemic control in Type I diabetic pregnancy; results of a nationwide study in The Netherlands [J].
Evers, IM ;
de Valk, HW ;
Mol, BWJ ;
ter Braak, EWMT ;
Visser, GHA .
DIABETOLOGIA, 2002, 45 (11) :1484-1489
[7]   RED-CELL AGE-RELATED-CHANGES OF HEMOGLOBINS AIA+B AND AIC IN NORMAL AND DIABETIC SUBJECTS [J].
FITZGIBBONS, JF ;
KOLER, RD ;
JONES, RT .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (04) :820-824
[8]   GLYCOSYLATED HEMOGLOBIN (HBA1C) IN IRON-DEFICIENCY AND VITAMIN-B12 DEFICIENCY [J].
GRAMHANSEN, P ;
ERIKSEN, J ;
MOURITSANDERSEN, T ;
OLESEN, L .
JOURNAL OF INTERNAL MEDICINE, 1990, 227 (02) :133-136
[9]  
Hatakeyama I, 1999, IGAKU YAKUGAKU, V41, P1181
[10]   CORRELATION OF GLUCOSE REGULATION AND HEMOGLOBIN-A-IC IN DIABETES-MELLITUS [J].
KOENIG, RJ ;
PETERSON, CM ;
JONES, RL ;
SAUDEK, C ;
LEHRMAN, M ;
CERAMI, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (08) :417-425