The proliferation of human T lymphocytes stimulated by Helicobacter pylori antigens

被引：9

作者：

Chmiela, M ^{[1
]}

PaziakDomanska, B ^{[1
]}

Ljungh, A ^{[1
]}

Wadstrom, T ^{[1
]}

Rudnicka, W ^{[1
]}

机构：

[1] UNIV LODZ,INST MICROBIOL & IMMUNOL,LODZ,POLAND

来源：

IMMUNOBIOLOGY | 1996年 / 195卷 / 02期

关键词：

D O I：

10.1016/S0171-2985(96)80039-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fractionated mononuclear cells (MNCs) were obtained from peripheral blood of healthy human volunteers, seronegative for H. pylori antibodies. The MNCs were stimulated in culture with whole live or heat-killed H. pylori cells or with bacterial cell surface (SA) or cytoplasmic (CA) antingens. There was a marked proliferative response of T cells in cultures stimulated with 10(5) cells/well of live H. pylori, 5 mu g/well of CA or 5-20 mu g/well of SA. However, no proliferation was observed in MNC cultures containing higher ''doses'' of live H. pylori organisms (10(7)/well) or CA (20 mu/well). Moreover, higher ''doses'' of the bacteria or CA entirely inhibited the response of T cells to PHA.

引用

页码：199 / 208

页数：10

共 25 条

[1] AFFINITY OF THE GASTRIC PATHOGEN HELICOBACTER-PYLORI FOR THE N-SULFATED GLYCOSAMINOGLYCAN HEPARAN-SULFATE
ASCENCIO, F
FRANSSON, LA
WADSTROM, T
[J]. JOURNAL OF MEDICAL MICROBIOLOGY, 1993, 38 (04) : 240 - 244
[2] CHMIELA M, 1994, FEMS IMMUNOL MED MIC, V9, P41, DOI 10.1111/j.1574-695X.1994.tb00472.x
[3] ATTACHMENT, INGESTION AND INTRACELLULAR KILLING OF HELICOBACTER-PYLORI BY HUMAN PERIPHERAL-BLOOD MONONUCLEAR LEUKOCYTES AND MOUSE PERITONEAL INFLAMMATORY MACROPHAGES
CHMIELA, M
PAZIAKDOMANSKA, B
WADSTROM, T
[J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1995, 10 (3-4): : 307 - 316
[4] SYSTEMIC AND MUCOSAL HUMORAL RESPONSES TO HELICOBACTER-PYLORI IN GASTRIC-CANCER
CRABTREE, JE
WYATT, JI
SOBALA, GM
MILLER, G
TOMPKINS, DS
PRIMROSE, JN
MORGAN, AG
[J]. GUT, 1993, 34 (10) : 1339 - 1343
[5] CRABTREE JE, 1993, J GASTROEN HEPATOL, V5, P30
[6] DEMAGISTRIS MT, 1993, EUR J GASTROEN HEPAT, V5, P25
[7] HELICOBACTER PYLORI-SPECIFIC CD4(+) T-CELL CLONES FROM PERIPHERAL-BLOOD AND GASTRIC BIOPSIES
DITOMMASO, A
XIANG, ZY
BUGNOLI, M
PILERI, P
FIGURA, N
BAYELI, PF
RAPPUOLI, R
ABRIGNANI, S
DEMAGISTRIS, MT
[J]. INFECTION AND IMMUNITY, 1995, 63 (03) : 1102 - 1106
[8] PRODUCTION OF ANTIBODY BY HUMAN B-CELLS UNDER SERUM-FREE CONDITIONS
FARRANT, J
NEWTON, CA
NORTH, ME
WEYMAN, C
BRENNER, MK
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1984, 68 (1-2) : 25 - 34
[9] HUNT SV, 1987, LYMPHOCYTES PRACTICA, P28
[10] THE RESPONSE OF CELLS FROM LOW-GRADE B-CELL GASTRIC LYMPHOMAS OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE TO HELICOBACTER-PYLORI
HUSSELL, T
ISAACSON, PG
CRABTREE, JE
SPENCER, J
[J]. LANCET, 1993, 342 (8871) : 571 - 574

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