Stereochemical elucidation of the pentacyclopropane antifungal agent FR-900848

被引：42

作者：

Barrett, AGM ^{[1
]}

Doubleday, WW ^{[1
]}

Kasdorf, K ^{[1
]}

Tustin, GJ ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 10期

关键词：

D O I：

10.1021/jo960054k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Full structural elucidation of FR-900848, an antifungal pentacyclopropane nucleoside natural product from Streptoverticillium fervens, is reported. A series of model compounds were prepared using multiple asymmetric Simmons-Smith cyclopropanation reactions. Comparisons of spectroscopic data of synthetic alkenes 9 and 10, quatercyclopropanes 11 and 12, and imidazolidines 13 and 14 with FR-900848 and its degradation products 2, 3, and 4 were consistent with the full structural assignment of the natural product as structure 7.

引用

页码：3280 / 3288

页数：9

共 35 条

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