Recognition of polarized lipid bilayers by p-oligophenyl ion channels:: From push-pull rods to push-pull barrels

被引：64

作者：

Sakai, N ^{[1
]}

Matile, S ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 07期

关键词：

D O I：

10.1021/ja017497c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Design, synthesis, and evaluation of 14-methoxy-84-methylsulfonyl-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (1) and 14,84-bismethoxy-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (2) are described (Gla = -OCH2CO-). Nanomolar concentrations of push-pull rod 1 are found to suffice to selectively form ion channels in polarized spherical bilayer membranes composed of egg yolk phosphatidylcholine. Exponential dependence of the ion-channel activity on membrane polarization reveals a gating charge of 0.85/channel. Independence of the activity of push-push rod 2 on membrane potential demonstrates that cell membrane recognition originates from the axial dipole in push-pull rod 1. Nonlinear concentration dependence of activity at -180 mV indicates parallel self-assembly of push-pull rod 1 into a tetrameric barrel-stave supramolecule. Copyright © 2002 American Chemical Society.

引用

页码：1184 / 1185

页数：2

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