Scrapie Resistance in ARQ Sheep

被引：38

作者：

Laegreid, W. W. ^{[1
]}

Clawson, M. L. ^{[2
]}

Heaton, M. P. ^{[2
]}

Green, B. T. ^{[3
]}

O'Rourke, K. I. ^{[4
]}

Knowles, D. P. ^{[4
]}

机构：

[1] Univ Illinois, Dept Pathobiol, Urbana, IL 61802 USA

[2] ARS, Anim Hlth Res Unit, Meat Anim Res Ctr, USDA, Clay Ctr, NE 68933 USA

[3] ARS, Poisonous Plant Res Lab, USDA, Logan, UT 84341 USA

[4] ARS, Anim Dis Res Unit, USDA, Pullman, WA 99163 USA

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 20期

关键词：

D O I：

10.1128/JVI.00710-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Variation in the ovine prion protein amino acid sequence influences scrapie progression, with sheep homozygous for A(136)R(154)Q(171) considered susceptible. This study examined the association of survival time of scrapie-exposed ARQ sheep with variation elsewhere in the ovine prion gene. Four single nucleotide polymorphism alleles were associated with prolonged survival. One nonsynonymous allele (T112) was associated with an additional 687 days of survival for scrapie-exposed sheep compared to M112 sheep (odds ratio, 42.5; P = 0.00014). The only two sheep homozygous for T112 (TARQ) did not develop scrapie, suggesting that the allelic effect may be additive. These results provide evidence that TARQ sheep are genetically resistant to development of classical scrapie.

引用

页码：10318 / 10320

页数：3

共 22 条

[11] Prion diseases:: BSE in sheep bred for resistance to infection [J].

Houston, F ;

Goldmann, W ;

Chong, A ;

Jeffrey, M ;

González, L ;

Foster, J ;

Parnham, D ;

Hunter, N .

NATURE, 2003, 423 (6939) :498-498

[12] AMINO-ACID POLYMORPHISMS OF PRP WITH REFERENCE TO ONSET OF SCRAPIE IN SUFFOLK AND CORRIEDALE SHEEP IN JAPAN [J].

IKEDA, T ;

HORIUCHI, M ;

ISHIGURO, N ;

MURAMATSU, Y ;

KAIUWE, GD ;

SHINAGAWA, M .

JOURNAL OF GENERAL VIROLOGY, 1995, 76 :2577-2581

[13] PRP POLYMORPHISMS ASSOCIATED WITH NATURAL SCRAPIE DISCOVERED BY DENATURING GRADIENT GEL-ELECTROPHORESIS [J].

LAPLANCHE, JL ;

CHATELAIN, J ;

WESTAWAY, D ;

THOMAS, S ;

DUSSAUCY, M ;

BRUGEREPICOUX, J ;

LAUNAY, JM .

GENOMICS, 1993, 15 (01) :30-37

[14] Epidemiological and genetical differences between classical and atypical scrapie cases [J].

Luehken, Gesine ;

Buschmann, Anne ;

Brandt, Horst ;

Eiden, Martin ;

Groschup, Martin H. ;

Erhardt, Georg .

VETERINARY RESEARCH, 2007, 38 (01) :65-80

[15] PolyPhred: Automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing [J].

Nickerson, DA ;

Tobe, VO ;

Taylor, SL .

NUCLEIC ACIDS RESEARCH, 1997, 25 (14) :2745-2751

[16] PrP genotypes and experimental scrapie in orally inoculated Suffolk sheep in the United States [J].

ORourke, KI ;

Holyoak, GR ;

Clark, WW ;

Mickelson, JR ;

Wang, S ;

Melco, RP ;

Besser, TE ;

Foote, WC .

JOURNAL OF GENERAL VIROLOGY, 1997, 78 :975-978

[17] PrP genotypes of atypical scrapie cases in Great Britain [J].

Saunders, G. C. ;

Cawthraw, S. ;

Mountjoy, S. J. ;

Hope, J. ;

Windl, O. .

JOURNAL OF GENERAL VIROLOGY, 2006, 87 :3141-3149

[18] Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation [J].

Stephens, M ;

Scheet, P .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (03) :449-462

[19] A new statistical method for haplotype reconstruction from population data [J].

Stephens, M ;

Smith, NJ ;

Donnelly, P .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (04) :978-989

[20] Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy [J].

Vaccari, Gabriele ;

D'Agostino, Claudia ;

Nonno, Romolo ;

Rosone, Francesca ;

Conte, Michela ;

Di Bari, Michele Angelo ;

Chiappini, Barbara ;

Esposito, Elena ;

De Grossi, Luigi ;

Giordani, Francesco ;

Marcon, Stefano ;

Morelli, Luisella ;

Borroni, Renata ;

Agrimi, Umberto .

JOURNAL OF VIROLOGY, 2007, 81 (13) :7306-7309

← 1 2 3 →