Sertindole

Sertindole is a novel and atypical antipsychotic compound. The drug selectively inhibits limbic dopamine function and is notable for its high in vitro affinity for dopamine D-2 receptors, serotonin 5-HT2 receptors and alpha(1)-adrenergic receptors. Sertindole shows marked antipsychotic activity in various animal models while lacking marked cataleptogenic, anticholinergic and autonomic activity, Results of phase II and III clinical studies have shown sertindole to be effective in alleviating the positive and negative symptoms of schizophrenia, Sertindole was not associated with disturbed motor function (including extrapyramidal symptoms) in phase II and III clinical studies.