Regulation of pre-mRNA splicing in metazoa

被引：98

作者：

Wang, J

Manley, JL

机构：

[1] Department of Biological Sciences, Columbia University, Sherman Fairchild Ctr. for Life Sci., New York, NY 10027

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(97)80130-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have identified additional cis-acting sequence elements that can either positively or negatively regulate pre-mRNA splicing. Trans-acting protein factors involved in tissue-specific splicing regulation have been characterized. The functions of splicing factors have been explored in vivo and certain splicing factors have been demonstrated to be essential for proper development and cell viability. Kinases that can specifically phosphorylate splicing factors have been identified and phosphorylation has been shown to influence the activity of splicing factors, consistent with a role for phosphorylation in splicing regulation.

引用

页码：205 / 211

页数：7

共 53 条

[11] A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE
GUI, JF
LANE, WS
FU, XD
[J]. NATURE, 1994, 369 (6482) : 678 - 682
[12] CHARACTERIZATION BY CDNA CLONING OF 2 NEW HUMAN PROTEIN-KINASES - EVIDENCE BY SEQUENCE COMPARISON OF A NEW FAMILY OF MAMMALIAN PROTEIN-KINASES
HANES, J
VONDERKAMMER, H
KLAUDINY, J
SCHEIT, KH
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 244 (05) : 665 - 672
[13] THE DROSOPHILA SR PROTEIN RBP1 CONTRIBUTES TO THE REGULATION OF DOUBLESEX ALTERNATIVE SPLICING BY RECOGNIZING RBP1 RNA TARGET SEQUENCES
HEINRICHS, V
BAKER, BS
[J]. EMBO JOURNAL, 1995, 14 (16) : 3987 - 4000
[14] HIMMELSPACH M, 1996, RNA, V2, P794
[15] Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
Kanopka, A
Muhlemann, O
Akusjarvi, G
[J]. NATURE, 1996, 381 (6582) : 535 - 538
[16] PROTEIN-PROTEIN INTERACTIONS AND 5'-SPLICE-SITE RECOGNITION IN MAMMALIAN MESSENGER-RNA PRECURSORS
KOHTZ, JD
JAMISON, SF
WILL, CL
ZUO, P
LUHRMANN, R
GARCIABLANCO, MA
MANLEY, JL
[J]. NATURE, 1994, 368 (6467) : 119 - 124
[17] Trans-acting factors regulate the expression of CD44 splice variants
Konig, H
Moll, J
Ponta, H
Herrlich, P
[J]. EMBO JOURNAL, 1996, 15 (15) : 4030 - 4039
[18] SYNERGISTIC INTERACTIONS BETWEEN 2 DISTINCT ELEMENTS OF A REGULATED SPLICING ENHANCER
LYNCH, KW
MANIATIS, T
[J]. GENES & DEVELOPMENT, 1995, 9 (03) : 284 - 293
[19] Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer
Lynch, KW
Maniatis, T
[J]. GENES & DEVELOPMENT, 1996, 10 (16) : 2089 - 2101
[20] MADHANI HD, 1994, ANNU REV GENET, V28, P126

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