Regulation of monocytes and macrophages cell fate

被引:69
作者
Gonzalez-Mejia, M. Elba [1 ,2 ,3 ]
Doseff, Andrea I. [1 ,2 ,3 ]
机构
[1] Ohio State Univ, Heart & Lung Res Inst, Columbus, OH 43220 USA
[2] Ohio State Univ, Dept Internal Med, Div Pulm & Crit Care, Columbus, OH 43220 USA
[3] Ohio State Univ, Dept Mol Genet, Columbus, OH 43220 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷
基金
美国国家科学基金会;
关键词
Apoptosis; Caspases; Monocytes; Macrophages; Hsp27; inflammation; survival; PKC Delta; CD14(+); CD16(+); REVIEW; TOLL-LIKE RECEPTOR; KINASE-C-DELTA; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; PRO-INFLAMMATORY CYTOKINES; HUMAN LEUKEMIA-CELLS; TEFLON CULTURE BAG; CLASS-II MOLECULES; HUMAN-BONE MARROW; BLOOD MONOCYTES;
D O I
10.2741/3387
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Monocytes and macrophages are central cells of the innate immune system, responding to a diverse repertoire of pathogens. These cells originate from a common myeloid precursor in the bone marrow and while sharing responsibilities during innate immunity, differ greatly in their lifespan. Normally, blood monocytes live for just few days before undergoing apoptosis. Macrophages, in contrast, live up for months. Monocytes' lifespan can switch dramatically, from prolonged survival during inflammation to apoptosis as inflammation resolves. Interestingly, many of the mechanisms mediating survival during inflammation and cancer also operate in monocyte/macrophage differentiation. Differentiation and inflammatory stimuli determine monocyte/macrophage lifespan, by blocking the apoptotic pathway and activating a myriad of survival pathways. How these complicated networks of survival and apoptotic regulators are integrated remains yet to be fully elucidated. The present review summarizes the different monocytes' subpopulations and their function during pathogen recognition. We discuss the role of the caspases and the mechanisms that determine monocytes/macrophages fate highlighting their significance in the regulation of inflammatory diseases.
引用
收藏
页码:2413 / 2431
页数:19
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