Glomerular ultrafiltration and apical tubular action of IGF-I, TGF-β, and HGF in nepbrotic syndrome

被引：36

作者：

Wang, SN ^{[1
]}

LaPage, J ^{[1
]}

Hirschberg, R ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Harbor Med Ctr, Div Nephrol, Torrance, CA 90509 USA

来源：

KIDNEY INTERNATIONAL | 1999年 / 56卷 / 04期

关键词：

apical tubular receptors; tubulointerstitial nephritis; proteinuria; progressive renal disease;

D O I：

10.1046/j.1523-1755.1999.00698.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In nephrotic glomerulopathies, there is ultrafiltration of high molecular weight forms of insulin-like growth factor-I (IGF-I), hepatocyte growth factor (HGF), and transforming growth factor-beta (TGF-beta), which are bioactive in tubular fluid and act through apical tubular receptors. Experimental evidence indicates that ultrafiltered IGF-I, HGF, and TGF-beta may contribute to increased tubular phosphate and sodium absorption, synthesis of extracellular matrix proteins, and secretion of chemokines such as monocyte chemoattractant protein-1 (MCP-1). Through these mechanisms, glomerular proteinuria may contribute to tubulointerstitial pathobiology in nephrotic syndrome.

引用

页码：1247 / 1251

页数：5

共 18 条

[1] Localization of TGF-β and its receptors in the kidney [J].

Ando, T ;

Okuda, S ;

Yanagida, T ;

Fujishima, M .

MINERAL AND ELECTROLYTE METABOLISM, 1998, 24 (2-3) :149-153

[2]

AUSTIN SM, 1993, J AM SOC NEPHROL, V3, P1358

[3]

Eddy AA, 1996, KIDNEY INT, V49, pS49

[4]

EDDY AA, 1994, J AM SOC NEPHROL, V5, P1273

[5] DISTRIBUTION OF IGF RECEPTORS IN THE PLASMA-MEMBRANE OF PROXIMAL TUBULAR CELLS [J].

HAMMERMAN, MR ;

ROGERS, S .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (05) :F841-F847

[6]

Hirschberg R, 1996, MINER ELECTROL METAB, V22, P128

[7] Bioactivity of glomerular ultrafiltrate during heavy proteinuria may contribute to renal tubulo-interstitial lesions - Evidence for a role for insulin-like growth factor [J].

Hirschberg, R .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (01) :116-124

[8] INSULIN-LIKE GROWTH-FACTOR-I AND ITS BINDING-PROTEINS IN THE EXPERIMENTAL NEPHROTIC SYNDROME [J].

HIRSCHBERG, R ;

KAYSEN, GA .

ENDOCRINOLOGY, 1995, 136 (04) :1565-1571

[9]

HIRSCHBERG R, 1995, J LAB CLIN MED, V126, P428

[10] Mechanisms of TGF-β-induced cell cycle arrest [J].

Hocevar, BA ;

Howe, PH .

MINERAL AND ELECTROLYTE METABOLISM, 1998, 24 (2-3) :131-135

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