Telomerase and telomeres: From basic biology to cancer treatment

被引：35

作者：

Helder, MN ^{[1
]}

Wisman, GBA ^{[1
]}

van der Zee, AGJ ^{[1
]}

机构：

[1] Univ Groningen Hosp, Dept Gynecol Oncol, NL-9700 RB Groningen, Netherlands

来源：

CANCER INVESTIGATION | 2002年 / 20卷 / 01期

关键词：

cancer treatment; hTR; hTERT; telomerase; telomere;

D O I：

10.1081/CNV-120000370

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The limited capacity to divide is one of the major differences between normal somatic cells and cancerous cells. This finite life span' of somatic cells is closely linked to loss of telomeric DNA at telomeres, the 'chromosome caps' consisting of repeated (TTAGGG) sequences. In more than 85% of advanced cancers, this telomeric attrition is compensated by telomerase, 'the immortality enzyme', implying that telomerase inhibition may restore mortality in tumor cells. This review discusses the progress in research on the structure and function of telomeres and the telomerase holoenzyme. In addition, new developments in telomere/telomerase targeting compounds such as antisense oligonucleotides and G-quadritplex stabilizing substances, but also new telomerase expression-related strategies such as telomerase promoter-driven suicide gene therapy and telomerase immunotherapy will be presented. It will be discussed how these data call be implemented in telomerase-directed therapies.

引用

页码：82 / 101

页数：20

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