TALE nucleases: tailored genome engineering made easy

被引：137

作者：

Mussolino, Claudio ^{[1
]}

Cathomen, Toni ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Expt Hematol, D-3000 Hannover, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2012年 / 23卷 / 05期

关键词：

ZINC-FINGER NUCLEASES; DNA-BINDING SPECIFICITY; DOUBLE-STRAND BREAKS; EMBRYONIC STEM-CELLS; HOMOLOGOUS RECOMBINATION; EFFECTOR NUCLEASES; MAJOR DETERMINANT; KNOCKOUT RATS; III EFFECTORS; CLEAVAGE;

D O I：

10.1016/j.copbio.2012.01.013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Custom-made designer nucleases have evolved into an indispensable platform to precisely alter complex genomes for basic research, biotechnology, synthetic biology, or human gene therapy. In this review we describe how transcription activator-like effector nucleases (TALENs) have rapidly developed into a chief technology for targeted genome editing in different model organisms as well as human stem cells. We summarize the technological background and provide an overview of the current state-of-the-art of TALENs with regard to activity and specificity of these nucleases for targeted genome engineering.

引用

页码：644 / 650

页数：7

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