Genetic Variation in Sodium-Dependent Vitamin C Transporters SLC23A1 and SLC23A2 and Risk of Advanced Colorectal Adenoma

被引：34

作者：

Erichsen, Hans Christian ^{[1
]}

Peters, Ulrike ^{[2
,3
,4
]}

Eck, Peter ^{[5
]}

Welch, Robert ^{[6
]}

Schoen, Robert E. ^{[7
]}

Yeager, Meredith ^{[6
]}

Levine, Mark ^{[5
]}

Hayes, Richard B. ^{[2
]}

Chanock, Stephen ^{[6
]}

机构：

[1] NCI, Sect Genom Variat, Pediat Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[2] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA

[3] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[4] Univ Washington, Seattle, WA 98195 USA

[5] NIDDKD, Mol & Clin Nutr Sect, Bethesda, MD 20892 USA

[6] NCI, Core Genotyping Facil, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[7] Univ Pittsburgh, Pittsburgh, PA USA

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2008年 / 60卷 / 05期

关键词：

D O I：

10.1080/01635580802033110

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous observational studies suggest that vitamin C may reduce risk of colorectal cancer. Vitamin C transport is facilitated by membrane bound sodium-dependent transporters, SVCT1 (encoded by SLC23A1) and SVCT2 (encoded by SLC23A2). To investigate if common genetic variants in these two genes are associated with risk of colorectal tumor development, we conducted a case-control study of 656 Caucasian advanced distal colorectal adenoma cases and 665 Caucasian sigmoidoscopy-negative controls nested within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association. For SLC23A2, overall, there was no association with baplotypes, but two SNPs located in intron 8 and exon 11 could be associated (odds ratio = 0.49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C). The findings should be confirmed in follow-up studies, and further investigation is required to probe the functional basis of this finding.

引用

页码：652 / 659

页数：8

共 36 条

[31] Is shorter always better? Relative importance of questionnaire length and cognitive ease on response rates and data quality for two dietary questionnaires [J].

Subar, AF ;

Ziegler, RG ;

Thompson, FE ;

Johnson, CC ;

Weissfeld, JL ;

Reding, D ;

Kavounis, KH ;

Hayes, RB .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2001, 153 (04) :404-409

[32] A family of mammalian Na+-dependent L-ascorbic acid transporters [J].

Tsukaguchi, H ;

Tokui, T ;

Mackenzie, B ;

Berger, UV ;

Chen, XZ ;

Wang, YX ;

Brubaker, RF ;

Hediger, MA .

NATURE, 1999, 399 (6731) :70-75

[33] Human Na+-dependent vitamin C transporter 1 (hSVCT1):: primary structure, functional characteristics and evidence for a non-functional splice variant [J].

Wang, HP ;

Dutta, B ;

Huang, W ;

Devoe, LD ;

Leibach, FH ;

Ganapathy, V ;

Prasad, PD .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1461 (01) :1-9

[34] Ascorbate recycling in human neutrophils: Induction by bacteria [J].

Wang, YH ;

Russo, TA ;

Kwon, O ;

Chanock, S ;

Rumsey, SC ;

Levine, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13816-13819

[35]

WASHKO PW, 1993, J BIOL CHEM, V268, P15531

[36] Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals [J].

Zaykin, DV ;

Westfall, PH ;

Young, SS ;

Karnoub, MA ;

Wagner, MJ ;

Ehm, MG .

HUMAN HEREDITY, 2002, 53 (02) :79-91

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