Fecal Markers: Calprotectin and Lactoferrin

被引：77

作者：

Abraham, Bincy P. ^{[1
]}

Kane, Sunanda ^{[2
]}

机构：

[1] Baylor Coll Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA

[2] Mayo Clin, Coll Med, Sect Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2012年 / 41卷 / 02期

关键词：

Calprotectin; Lactoferrin; Fecal markers; Crohn disease; Ulcerative colitis; Inflammatory bowel disease; INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; SURROGATE MARKERS; ILEAL POUCH; PREDICTIVE MARKER; BLOOD LEUKOCYTES; RELAPSE; BIOMARKERS;

D O I：

10.1016/j.gtc.2012.01.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonspecific gastrointestinal symptoms are present in both inflammatory and noninflammatory conditions. Noninvasive diagnostic tools include the fecal markers, calprotectin and lactoferrin. These are stable proteins that are present in the stool of patients with active and chronic inflammation. Studies have shown their ability to discriminate in a reproducible fashion the presence of inflammation with excellent correlation to endoscopic findings. These markers can also be used for predicting a disease flare as well as monitoring the success of treatment. Noninvasive stool markers are a convenient and reliable clinical tool that can be used in clinical practice.

引用

页码：483 / +

页数：14

共 47 条

[31] Fecal calprotectin as a predictor of abnormal colonic histology [J].

Shitrit, Ariella Bar-Gil ;

Braverman, Dan ;

Stankiewics, Halina ;

Shitrit, David ;

Peled, Nir ;

Paz, Kalman .

DISEASES OF THE COLON & RECTUM, 2007, 50 (12) :2188-2193

[32] Fecal Calprotectin, Lactoferrin, and Endoscopic Disease Activity in Monitoring Anti-TNF-alpha Therapy for Crohn's Disease [J].

Sipponen, Taina ;

Savilahti, Erkki ;

Karkkainen, Paivi ;

Kolho, Kaija-Leena ;

Nuutinen, Hannu ;

Turunen, Ulla ;

Farkkila, Martti .

INFLAMMATORY BOWEL DISEASES, 2008, 14 (10) :1392-1398

[33]

Sugi K, 1996, AM J GASTROENTEROL, V91, P927

[34] Assessment of ileal pouch inflammation by single-stool calprotectin assay [J].

Thomas, P ;

Rihani, H ;

Roseth, A ;

Sigthorsson, G ;

Price, A ;

Nicholls, RJ ;

Bjarnason, I .

DISEASES OF THE COLON & RECTUM, 2000, 43 (02) :214-220

[35] A simple method for assessing intestinal inflammation in Crohn's disease [J].

Tibble, J ;

Teahon, K ;

Thjodleifsson, B ;

Roseth, A ;

Sigthorsson, G ;

Bridger, S ;

Foster, R ;

Sherwood, R ;

Fagerhol, M ;

Bjarnason, I .

GUT, 2000, 47 (04) :506-513

[36] Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease [J].

Tibble, JA ;

Sigthorsson, G ;

Bridger, S ;

Fagerhol, MK ;

Bjarnason, I .

GASTROENTEROLOGY, 2000, 119 (01) :15-22

[37] Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease [J].

Tibble, JA ;

Sigthorsson, G ;

Foster, R ;

Forgacs, I ;

Bjarnason, I .

GASTROENTEROLOGY, 2002, 123 (02) :450-460

[38] IMMUNOCHEMICAL DETECTION OF HUMAN LACTOFERRIN IN FECES AS A NEW MARKER FOR INFLAMMATORY GASTROINTESTINAL DISORDERS AND COLON-CANCER [J].

UCHIDA, K ;

MATSUSE, R ;

TOMITA, S ;

SUGI, K ;

SAITOH, O ;

OHSHIBA, S .

CLINICAL BIOCHEMISTRY, 1994, 27 (04) :259-264

[39]

van der Sluys VA, 1999, SCAND J GASTROENTE S, VS230, P106

[40]

Van Rheenen PF, 2010, Bmj, V341

← 1 2 3 4 5 →