N-linked carba-disaccharides as potential inhibitors of glucosidases I and II

被引：10

作者：

Carvalho, I ^{[1
]}

Haines, AH ^{[1
]}

机构：

[1] Univ E Anglia, Sch Chem Sci, Norwich NR4 7TJ, Norfolk, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 13期

关键词：

D O I：

10.1039/a902826i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An N-linked pseudodisaccharide 2 containing an inositol moiety in place of a glycopyranosyl residue has been synthesised to mimic the disaccharide unit, 3-O-(alpha-D-glucopyranosyl)-D-glucopyranose cleaved by glucosidase II during glycoprotein processing. Its inhibitory action towards yeast alpha-glucosidase was inferior to that of 1-deoxynojirmycin, a known inhibitor of glucosidase II. An attempt to prepare the analogous 2-N-linked compound 1 as an inhibitor of glucosidase I led to the novel N-phenyl derivative 11 of 2-amino-2-deoxy-D-glucopyranose.

引用

页码：1795 / 1800

页数：6

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