Disturbed sleep in Parkinson's disease: anatomical and pathological correlates

被引：64

作者：

Kalaitzakis, M. E. ^{[1
]}

Gentleman, S. M. ^{[1
]}

Pearce, R. K. B. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Brain Sci, Neuropathol Unit, London W6 8RP, England

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 2013年 / 39卷 / 06期

关键词：

dementia; Lewy body disease; neuropathology; Parkinson's disease; sleep; EYE-MOVEMENT SLEEP; BRAINNET EUROPE CONSORTIUM; REM BEHAVIOR DISORDER; EXCESSIVE DAYTIME SLEEPINESS; ALPHA-SYNUCLEIN PATHOLOGY; LEWY BODY DISEASE; NEURODEGENERATIVE DISEASE; DEMENTIA; BODIES; AMYGDALA;

D O I：

10.1111/nan.12024

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aims: Abnormal sleep is a common feature of Parkinson's disease (PD) and prodromal disorders of sleep are frequent (e. g. restless legs syndrome and rapid eye movement sleep behaviour disorder). However, the exact pathological basis of disturbed sleep remains as yet undefined. Methods: To investigate this further, 32 PD cases were stratified into three groups: (1) PD with disturbed sleep, PD(S); (2) PD with dementia (PDD) and disturbed sleep, PDD(S); and (3) PD without disturbed sleep, PD(nS). The extent of a-synuclein (aSyn) and Alzheimer disease (AD)-type pathology [amyloid b peptide (Ab) and tau] was assessed in 15 regions of the PD brain. Results: The results demonstrate a significant association between disturbed sleep in PD and aSyn pathology in specific brainstem [locus coeruleus (P = 0.006) and raphe nuclei (P = 0.02)], hypothalamic [paramammillary nuclei (P = 0.04) and posterior nucleus (P = 0.02)], subcortical/limbic [amygdala (P = 0.03), thalamus (P = 0.01)] and cortical [entorhinal cortex (P = 0.01)] regions. A statistically significant increase of tau pathology was observed in the amygdala (P = 0.03), CA2 sector of the hippocampus (P = 0.01) and entorhinal cortex (P = 0.04) in PD cases with disturbed sleep. Conclusions: Pathological changes in these structures, residing in the brain circuitry relating to sleep physiology, strongly predict the presence of sleep disturbances in PD.

引用

页码：644 / 653

页数：10

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