Immunolocalization of cyclooxygenase-2 in the macula densa of human elderly

被引：106

作者：

Nantel, F

Meadows, E

Denis, D

Connolly, B

Metters, KM

Giaid, A

机构：

[1] Merck Frosst Ctr Therapeut Res, Dept Biochem & Mol Biol, Pointe Claire, PQ H9R 4P8, Canada

[2] Merck Res Labs, Dept Human Genet, West Point, PA 19486 USA

[3] Montreal Gen Hosp, Montreal, PQ H3G 1A4, Canada

来源：

FEBS LETTERS | 1999年 / 457卷 / 03期

关键词：

kidney; human; cyclooxygenase; macula densa; immunohistology;

D O I：

10.1016/S0014-5793(99)01088-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To gain insight into the role of prostanoids in human kidney function, we examined the distribution of cyclooxygenase (COX) 1 and COX-2 by immunofluorescence and immunohistochemistry in human kidneys from adults of various age groups. COX-1 was detected in the collecting ducts, thin loops of Henle and portions of the renal vasculature, COX-2 was detected in the renal vasculature, medullary interstitial cells, and the macula densa, In addition, COX-2 immunoreactivity was noted in afferent arteries and the macula densa of the renal cortex and was more evident in the kidneys of older adults. (C) 1999 Federation of European Biochemical Societies.

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收藏

页码：475 / 477

页数：3

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