Ion Mobility-Mass Spectrometer Interface for Collisional Activation of Mobility Separated Ions

被引：15

作者：

Fernandez-Lima, Francisco A. ^{[1
]}

Becker, Christopher ^{[1
]}

Gillig, Kent J. ^{[1
]}

Russell, William K. ^{[1
]}

Tichy, Shane E. ^{[1
]}

Russell, David H. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

ANALYTICAL CHEMISTRY | 2009年 / 81卷 / 02期

基金：

美国国家科学基金会;

关键词：

LASER-DESORPTION IONIZATION; RESOLVED MAGNETIC DISPERSION; POST-SOURCE DECAY; INDUCED DISSOCIATION; LIQUID-CHROMATOGRAPHY; BIOMOLECULAR IONS; DRIFT-TUBE; GAS-PHASE; TRAP; REFLECTRON;

D O I：

10.1021/ac801919n

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An ion mobility-mass spectrometer (IM-MS) interface is described that can be employed to perform collisional activation and/or collision-induced dissociation (CID) with good transmission of mobility separated ions to the MS analyzer. The IM-MS interface consists of a stacked-ring ion guide design, where the field strength and pressure ratio can be operated such that structural rearrangement reactions and/or CID are achieved as a function of the effective ion temperature. The ion dynamics and collisional activation processes in the IM-MS interface are described as a function of the ion-neutral collisions, ion kinetic energies, and effective ion temperature. The applicability of the IM-CID-MS methodology to studies of peptide ion fragmentation is illustrated using a series of model peptides.

引用

页码：618 / 624

页数：7

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