Synthesis and potent anti-HIV activity of L-2′,3′-didehydro-2′,3′-dideoxy-2′-fluoro-4′-thiocytidine

被引：23

作者：

Choi, Y

Choo, H

Chong, Y

Lee, S

Olgen, S

Schinazi, RF

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

[2] Emory Univ, Sch Med, Vet Affairs Med Ctr, Decatur, GA 30033 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 02期

关键词：

D O I：

10.1021/ol0171665

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

GRAPHICS L-2'-Fluoro-4'-thio-2',3'-unsaturated cytidine 11 was synthesized from (R)-2-fluorobutenolide 2, which was prepared from 2,3-O-isopropylidene-L-glyceraldehyde 1. The synthesized compound 11 shows potent antiviral activity against HIV-1.

引用

页码：305 / 307

页数：3

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