A DAST-free route to aryl(difluoromethyl)phosphonic esters

被引:15
作者
Blades, K
Cockerill, GS
Easterfield, HJ
Lequeux, TP
Percy, JM
机构
[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
[2] GLAXO WELLCOME RES & DEV LTD,STEVENAGE SG1 2NY,HERTS,ENGLAND
关键词
D O I
10.1039/cc9960001615
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The cerium(III)-mediated addition of diethyl (lithiodifluoromethyl)phosphonate to a benzoquinone monoketal allows the synthesis of phenol bearing the (diethoxyphosphonyl)difluoromethyl group via short, scaleable reaction sequences which avoid the use of the DAST reagent.
引用
收藏
页码:1615 / 1616
页数:2
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