CARBONYLATIVE COUPLING OF AN AMINO ACID-DERIVED ORGANOZINC REAGENT WITH FUNCTIONALIZED ARYL IODIDES - SYNTHESIS OF KYNURENINE

被引：12

作者：

JACKSON, RFW ^{[1
]}

TURNER, D ^{[1
]}

BLOCK, MH ^{[1
]}

机构：

[1] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 21期

关键词：

D O I：

10.1039/c39950002207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The utility of the palladium(0) catalysed reaction of the serine-derived organozinc reagent 6 with functionalized aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo alpha-amino acids 8 is illustrated by a short synthesis of L-kynurenine.

引用

页码：2207 / 2208

页数：2

共 8 条

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[3] SYNTHESIS OF ENANTIOMERICALLY PURE UNSATURATED ALPHA-AMINO-ACIDS USING SERINE-DERIVED ZINZ/COPPER REAGENTS
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[4] PREPARATION OF ENANTIOMERICALLY PURE PROTECTED 4-OXO-ALPHA-AMINO ACIDS AND 3-ARYL-ALPHA-AMINO ACIDS FROM SERINE
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[5] REACTION OF A SERINE-DERIVED ORGANOZINC REAGENT WITH CHLOROFORMATES AND ETHYL OXALYL CHLORIDE UNDER PALLADIUM CATALYSIS - PREPARATION OF PROTECTED (2S,6S)-4-OXO-2,6-DIAMINOPIMELIC ACID AND (2S)-4-OXOGLUTAMIC ACID
JACKSON, RFW
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[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (21) : 1587 - 1589
[6] FACILE SYNTHESIS OF L-KYNURENINE
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[7] UNSYMMETRICAL KETONE SYNTHESIS VIA PALLADIUM CATALYZED CARBONYLATION OF ORGANIC HALIDES
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[J]. TETRAHEDRON LETTERS, 1983, 24 (36) : 3869 - 3872
[8] UNSYMMETRICAL KETONE SYNTHESIS VIA A 3-COMPONENT CONNECTION REACTION OF ORGANOZINCS, ALLYLATING AGENTS, AND CARBON-MONOXIDE
YASUI, K
FUGAMI, K
TANAKA, S
TAMARU, Y
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (05) : 1365 - 1380

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