CARBONYLATIVE COUPLING OF AN AMINO ACID-DERIVED ORGANOZINC REAGENT WITH FUNCTIONALIZED ARYL IODIDES - SYNTHESIS OF KYNURENINE

被引:12
作者
JACKSON, RFW [1 ]
TURNER, D [1 ]
BLOCK, MH [1 ]
机构
[1] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
关键词
D O I
10.1039/c39950002207
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The utility of the palladium(0) catalysed reaction of the serine-derived organozinc reagent 6 with functionalized aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo alpha-amino acids 8 is illustrated by a short synthesis of L-kynurenine.
引用
收藏
页码:2207 / 2208
页数:2
相关论文
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