Cytotoxic Activities of Diarylheptanoids from Alnus japonica

被引：38

作者：

Choi, Sun Eun ^{[1
]}

Kim, Kwang Ho ^{[1
]}

Kwon, Joo Hee ^{[1
]}

Kim, Seung Burn ^{[1
]}

Kim, Ha Won ^{[2
]}

Lee, Min Won ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea

[2] Univ Seoul, Dept Life Sci, Seoul 130743, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 10期

关键词：

Alnus japonica; Diarylheptanoid; Cytotoxic activity; B16 melanoma cell; Gastric cancer cell; Hepatoma cancer cell; Colorectal cell;

D O I：

10.1007/s12272-001-2108-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-beta-D-glucopyranosyl(1 -> 3)-beta-D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-beta-D-apiofuranosyl(1 -> 6)-beta-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-beta-D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)-5hydroxyheptane-3-O-beta-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. The cytotoxic activities of these ten compounds were evaluated against murine B 16 melanoma, human SNUI gastric cancer, human SNU-354 hepatoma cancer and human SNU-C4 colorectal cell lines. The diarylheptanoids showed potent cytotoxic activities against murine B16 melanoma cells and human SNUC1 gastric cancer cell when the cell viability was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay.

引用

页码：1287 / 1289

页数：3

共 13 条

[1]

Melanogenesis inhibitory activities of diarylheptanoids from Alnus hirsuta Turcz in B16 mouse melanoma cell [J].