Diarylheptanoids with in vitro inducible nitric oxide synthesis inhibitory activity from Alnus hirsuta

被引：41

作者：

Lee, MW

Kim, NY

Park, MS

Ahn, KH

Toh, SH

Hahn, DR

Kim, YC

Chung, HT ^{[1
]}

机构：

[1] Wonkwang Univ, Sch Med, Iksan 570749, Chonbuk, South Korea

[2] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea

[3] Dongduk Womans Univ, Coll Pharm, Seoul, South Korea

[4] Wonkwang Univ, Coll Pharm, Iksan, South Korea

[5] Med Resources Res Ctr, Iksan, South Korea

来源：

PLANTA MEDICA | 2000年 / 66卷 / 06期

关键词：

D O I：

10.1055/s-2000-8606

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four diarylheptanoids were isolated from the leaf of Alnus hirsuta (Betulaceae) and have been assessed for nitric oxide (NO) production inhibitory effects in vitro. Oregonin (1) and hirsutanonol (2) were found to be potent inducible nitric oxide synthase (iNOS) inhibitors. Compounds 1 and 2 showed inhibition of NO synthesis in dose-dependent manners by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). Their 50% inhibitory concentrations (IC50) were 3.8 and 14.3 mu M, respectively. The inhibitory effects of these compounds on NO synthesis were due to suppression of iNOS mRNA expression as determined by Northern blotting.

引用

页码：551 / 553

页数：3

共 12 条

[1]

AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303

[2]

CLANCY RM, 1995, P SOC EXP BIOL MED, V210, P93

[3]

Four new diarylheptanoid glycosides from Alnus rubra bark [J].

Gonzalez-Laredo, RF ;

Chen, J ;

Karchesy, YM ;

Karchesy, JJ .

NATURAL PRODUCT LETTERS, 1999, 13 (02) :75-80

[4]

Scopoletin:: An inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei [J].

Kang, TH ;

Pae, HO ;

Jeong, SJ ;

Yoo, JC ;

Choi, BM ;

Jun, CD ;

Chung, HT ;

Miyamoto, T ;

Higuchi, R ;

Kim, YC .

PLANTA MEDICA, 1999, 65 (05) :400-403

[5]

STRUCTURE OF OREGONIN, A NATURAL DIARYLHEPTANOID XYLOSIDE [J].

KARCHESY, JJ ;

LAVER, ML ;

BAROFSKY, DF ;

BAROFSKY, E .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1974, (16) :649-650

[6]

LEE MW, 1992, PHYTOCHEMISTRY, V31, P967, DOI 10.1016/0031-9422(92)80049-K

[7]

Lee S.J., 1996, KOREA FOLK MED, P40

[8]

MONCADA S, 1991, PHARMACOL REV, V43, P109

[9]

Sasaya T., 1985, ENSHURIN KENKYU HOKO, V42, P191

[10]

Terazawa M., 1973, Mokuzai Gakkaishi (Journal of the Japan Wood Research Society), V19, P45

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