Solid support synthesis of 2,4-disubstituted thiazoles and aminothiazoles

被引：30

作者：

El Kazzouli, S

Berteina-Raboin, S

Mouaddib, A

Guillaumet, G

机构：

[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt, F-45067 Orleans 2, France

[2] Univ Caddi Ayyad, Fac Sci & Tech, Beni Mellal, Morocco

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(02)00471-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Iodobenzoic acid was loaded on Rink amide resin. Pd(0) coupling reaction with tributyl(1-ethoxyvinyl)tin followed by bromination using NBS gave an alpha-bromoketone bound to a solid support. Condensation of thioamide or thiourea. followed by TFA cleavage from the resin, gave 2,4-disubstituted thiazoles or 2-aminothiazoles, respectively. The primary amine of aminothiazole was treated with various acyl or sulfonyl chlorides to provide 2-substituted thiazole analogs. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3193 / 3196

页数：4

共 11 条

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