Lysophosphatidic acid as a phospholipid mediator: Pathways of synthesis

被引：144

作者：

Gaits, F

Fourcade, O

LeBalle, F

Gueguen, G

Gaige, B

GassamaDiagne, A

Fauvel, J

Salles, JP

Mauco, G

Simon, MF

Chap, H

机构：

[1] UNIV TOULOUSE 3,INST FEDERAT RECH IMMUNOL CELLULAIRE & MOL,F-31059 TOULOUSE,FRANCE

[2] CHU TOULOUSE,HOP PURPAN,INSERM,U326,F-31059 TOULOUSE,FRANCE

来源：

FEBS LETTERS | 1997年 / 410卷 / 01期

关键词：

lysophosphatidic acid; phospholipase A(2); phospholipase A(1); diacylglycerol lipase; platelets;

D O I：

10.1016/S0014-5793(97)00411-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From very recent studies, including molecular cloning of cDNA coding for membrane receptors, Iysophosphatidic acid (LPA) reached the status of a novel phospholipid mediator with various biological activities. Another strong argument supporting this view was the discovery that LPA is secreted from activated platelets, resulting in its appearance in serum upon blood coagulation. The metabolic pathways as well as the enzymes responsible for LPA production are poorly characterized. However, a survey of literature data indicates some interesting issues which might be used as the basis for further molecular characterization of phospholipases A able to degrade phosphatidic acid. (C) 1997 Federation of European Biochemical Societies.

引用

页码：54 / 58

页数：5

共 57 条

[51] LYSOPHOSPHATIDATE-INDUCED CELL-PROLIFERATION - IDENTIFICATION AND DISSECTION OF SIGNALING PATHWAYS MEDIATED BY G-PROTEINS [J].