Chiral biferrocene-based bis(oxazolines): Ligands for Cu(I)-catalyzed asymmetric cyclopropanations of ene-diazoacetates

被引：28

作者：

Kim, SG

Cho, CW

Ahn, KH

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

[2] Pohang Univ Sci & Technol, Ctr Biofunct Mol, Pohang 790784, South Korea

来源：

TETRAHEDRON | 1999年 / 55卷 / 33期

关键词：

D O I：

10.1016/S0040-4020(99)00542-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral biferrocene-based bis(oxazoline) compounds, which have both planar and central chirality, are synthesized. The Cu(I)-complexes of the bis(oxazolinyl)biferrocenes were found to be conformationally flexible and have a wide bile angle (136 degrees) by NMR and molecular modeling studies. The complexes catalyzed the intramolecular cyclopropanation reaction of ene-diazoacetates, and low to moderate enantioselectivities and decreased reactivity were observed, compared to known malonate-derived bis(oxazoline) systems. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：10079 / 10086

页数：8

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