Small Molecule p38 MAP Kinase Inhibitors for the Treatment of Inflammatory Diseases: Novel Structures and Developments During 2006-2008

被引：71

作者：

Pettus, Liping H. ^{[1
]}

Wurz, Ryan P. ^{[1
]}

机构：

[1] Amgen Inc, Dept Med Chem, Thousand Oaks, CA 91320 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 16期

关键词：

D O I：

10.2174/156802608786264245

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The p38 mitogen-activated protein (MAP) kinase plays a central role in inflammation. It has been the subject of extensive efforts in both basic research and drug discovery for the treatment of inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, where aberrant cytokine signaling is the driver of the disease. This article reviews the patent and journal publication activities during 2006-2008 describing novel small molecule p38 alpha inhibitors.

引用

页码：1452 / 1467

页数：16

共 97 条

[41]

DYCKMAN AJ, 2008, Patent No. 20080004278

[42] Infliximab treatment results in significant improvement in the quality of life of patients with severe psoriasis: a double-blind placebo-controlled trial [J].

Feldman, SR ;

Gordon, KB ;

Bala, M ;

Evans, R ;

Li, S ;

Dooley, LT ;

Guzzo, C ;

Patel, K ;

Menter, A ;

Gottlieb, AB .

BRITISH JOURNAL OF DERMATOLOGY, 2005, 152 (05) :954-960

[43] Role of cytokines in rheumatoid arthritis [J].

Feldmann, M ;

Brennan, FM ;

Maini, RN .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :397-440

[44]

FERRACCIOLI GF, 2000, CURR OPIN ANTIINFLAM, V2, P74

[45] Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity [J].

Fitzgerald, CE ;

Patel, SB ;

Becker, JW ;

Cameron, PM ;

Zaller, D ;

Pikounis, VB ;

O'Keefe, SJ ;

Scapin, G .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (09) :764-769

[46]

FLYNN DL, 2008, Patent No. 7342037

[47]

FLYNN DL, 2006, Patent No. 2006014290

[48]

Foster ML, 2000, DRUG NEWS PERSPECT, V13, P488

[49]

GABRIEL T, 2007, CAMBRIDGE HEALTHTECH

[50] Protein kinases as small molecule inhibitor targets in inflammation [J].

Gaestel, M. ;

Mengel, A. ;

Bothe, U. ;

Asadullah, K. .

CURRENT MEDICINAL CHEMISTRY, 2007, 14 (21) :2214-2234

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