The ageing immune system: is it ever too old to become young again?

被引：301

作者：

Dorshkind, Kenneth ^{[1
]}

Montecino-Rodriguez, Encarnacion ^{[1
]}

Signer, Robert A. J. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

AGE-RELATED-CHANGES; BONE-MARROW; T-CELLS; CALORIC RESTRICTION; INFLUENZA VACCINES; STEM-CELLS; B-CELLS; SENESCENCE; CANCER; MICE;

D O I：

10.1038/nri2471

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ageing is accompanied by a decline in the function of the immune system, which increases susceptibility to infections and can decrease the quality of life. The ability to rejuvenate the ageing immune system would therefore be beneficial for elderly individuals and would decrease health-care costs for society. But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population.

引用

页码：57 / 62

页数：6

共 61 条

[31] Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
Messaoudi, Ilhem
Warner, Jessica
Fischer, Miranda
Park, Buyng
Hill, Brenna
Mattison, Julie
Lane, Mark A.
Roth, George S.
Ingram, Donald K.
Picker, Louis J.
Douek, Daniel C.
Mori, Motomi
Nikolich-Zugich, Janko
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (51) : 19448 - 19453
[32] The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
Miller, JP
Allman, D
[J]. JOURNAL OF IMMUNOLOGY, 2003, 171 (05) : 2326 - 2330
[33] B cells and aging: Balancing the homeostatic equation
Miller, Juli P.
Cancro, Michael P.
[J]. EXPERIMENTAL GERONTOLOGY, 2007, 42 (05) : 396 - 399
[34] Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
Min, Dullei
Panoskaltsis-Mortari, Angela
Kuro-o, Makoto
Hollaender, Georg A.
Blazar, Bruce R.
Weinberg, Kenneth I.
[J]. BLOOD, 2007, 109 (06) : 2529 - 2537
[35] Effects of aging on the common lymphoid progenitor to pro-B cell transition
Min, HY
Montecino-Rodriguez, E
Dorshkind, K
[J]. JOURNAL OF IMMUNOLOGY, 2006, 176 (02) : 1007 - 1012
[36] Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice
Montecino-Rodriguez, E
Clark, R
Dorshkind, K
[J]. ENDOCRINOLOGY, 1998, 139 (10) : 4120 - 4126
[37] Oncogene-induced cell senescence - Halting on the road to cancer
Mooi, W. J.
Peeper, D. S.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (10) : 1037 - 1046
[38] Growth hormone enhances thymic function in HIV-1-infected adults
Napolitano, Laura A.
Schmidt, Diane
Gotway, Michael B.
Ameli, Niloufar
Filbert, Erin L.
Ng, Myra M.
Clor, Julie L.
Epling, Lorrie
Sinclair, Elizabeth
Baum, Paul D.
Li, Kai
Killian, Marisela Lua
Bacchetti, Peter
McCune, Joseph M.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (03) : 1085 - 1098
[39] Mice and flies and monkeys too: Caloric restriction rejuvenates the aging immune system of non-human primates
Nikolich-Zugich, J
Messaoudi, I
[J]. EXPERIMENTAL GERONTOLOGY, 2005, 40 (11) : 884 - 893
[40] Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
Nikolich-Zugich, Janko
[J]. NATURE REVIEWS IMMUNOLOGY, 2008, 8 (07) : 512 - 522

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